9/19/2023 0 Comments Collaboratory definitionThese study findings indicate that gout and OSA are associated with each other, likely related to both sharing metabolic syndrome comorbidities. A study of the US Medicare population, mostly 65 years or older, revealed that gout was associated with a 2-fold higher risk of incident OSA. without baseline OSA, indicating the OSA may be a risk factor for gout. Another study examined the Health Improvement Network (THIN) database in the UK and found that the incidence of gout was increased by 50% in people with vs. An analysis of the 5% random US Medicare data showed that gout was independently associated with a 2-fold higher risk of OSA, after adjusting for demographics, comorbidity, cardiovascular disease, and medications used for the treatment of gout and cardiovascular disease. A recent case-control matched the UK study that used primary care/general practice data reported that gout was associated with 1.4-fold higher risk of any sleep problem, with 50% higher risk of OSA and 37% higher risk of non-sleep apnea problems. īoth gout and sleep apnea (a common form of sleep disorder) are associated with metabolic syndrome, defined as the presence of glucose intolerance, hypertension, atherogenic dyslipidemia, and obesity. Effective treatments are available for OSA and other sleep disorders that can reduce morbidity and improve quality of life and work productivity. OSA is associated with significant morbidity and reduced work productivity cardiovascular morbidity may be related to oxidative stress and inflammation. $150 billion in 2015 according to a recent report, and the health care savings with proper diagnosis could be $100 billion. Undiagnosed and un- or under-treated OSA was estimated to cost the U.S. Sleep disorders constitute a major public health burden for the US adults with a prevalence of 6% according to the National Health and Nutrition Examination Survey (NHANES) 2005–2006, obstructive sleep apnea (OSA) being the most common type. More in-depth studies are needed to better understand the association of gout with sleep disorders. People with physician-diagnosed gout reported frequent sleep disorders and daytime sleepiness in an Internet survey. Sleep quality was 5.5 (SD, 2.6), and daytime sleepiness was 3.5 (SD, 2.6) on a 0–10 scale (higher = worse). Two thirds of the patients reported feeling sleepy during the day, at least 3–4 times a month or more. Eighty-six percent reported snoring during sleep and 45% reported having snorted, gasped, or stopped breathing while asleep. A mean 6.7 h of sleep per night was reported (SD, 1.3). Of the respondents, 23% reported doctor-diagnosed sleep disorder (sleep apnea, 17% sleep study ordered, diagnosis pending, 4% other sleep disorder 2%). Mean age was 57 years (standard deviation, 13.4), 72% were male, 77% were White, and mean gout duration was 7.6 (SD, 11). Of the 454 website visitors who clicked the survey, 320 survey respondents reported physician-diagnosed gout. We used Chi-square test to compare the categorical and t test the continuous variables. MethodsĪ brief anonymized Internet survey of people with physician-diagnosed gout who visited a gout education website assessed the frequency of sleep problems, sleep quality over the past 24 h (0 = best possible sleep, 10 = worst possible sleep), daytime sleepiness on a typical day (0 = none and 10 = most sleepy during the day), sleep quantity (number of hours of sleep), and the frequency of snoring or gasping, and snorting or stopping breathing during the sleep, using validated questionnaires, including the NHANES 2016 sleep questionnaire. Our objective was to assess the burden of sleep disorders in people with gout. Limited information exists regarding sleep disorders in gout.
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